Drug General Information
Drug ID	D03CGQ
Former ID	DIB004142
Drug Name	AG-013958
Synonyms	AG-13958
Indication	Age related macular degeneration [ICD9: 362.5; ICD10:H35.3]		Phase 1/2	[521610]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	VEGF receptor	Target Info	Inhibitor	[544034]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Transcriptional misregulation in cancer
	Rheumatoid arthritis
References
Ref 521610	ClinicalTrials.gov (NCT00090532) A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration. U.S. National Institutes of Health.
Ref 544034	Receptor Tyrosine Kinase Inhibitors AG013764 and AG013711 Reduce Choroidal Neovascularization in Rat Eye. Exp Eye Res. 2007 May; 84(5): 922-933.

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