Drug Information

Drug General Information
Drug ID
D03DIG
Former ID
DAP000213
Drug Name
Codeine
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538268], [539036]
Cough [ICD9: 786.2; ICD10:R05] Phase 1 [533409], [539036]
Therapeutic Class
Analgesics
Company
Forest Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C18H21NO3
InChIKey
OROGSEYTTFOCAN-DNJOTXNNSA-N
CAS Number
CAS 76-57-3
PubChem Compound ID
5284371
PubChem Substance ID
8425, 841961, 7978983, 8144934, 11039235, 14825207, 15419416, 24892429, 24892819, 28325869, 39317728, 46507764, 48413480, 48415816, 48423163, 49855816, 50881119, 53788605, 57653987, 57654027, 87544102, 92710514, 103169342, 103930322, 104000895, 117497011, 124954734, 126631803, 126678046, 128851630, 134337528, 134971680, 135650117, 137001257, 137175320, 142842434, 144207280, 152094958, 160963666, 164838528, 175268396, 175442317, 179151116, 223554832, 223680835, 223739746, 226395484, 241129665
ChEBI ID
ChEBI:16714
SuperDrug ATC ID
R05DA04
SuperDrug CAS ID
cas=000076573
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [536098]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 533409Effects of a mu-opioid receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man. Br J Clin Pharmacol. 1986 Nov;22(5):507-12.
Ref 538268FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074256.
Ref 539036(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673).
Ref 536098Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. Epub 2005 Jun 8.

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