Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03ESO
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| Former ID |
DPR000055
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| Drug Name |
GW-3333
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| Synonyms |
GW3333; Gw 3333; N2-[(2r,3s)-3-[formyl(hydroxy)amino]-4-methyl-2-(2-methylpropyl)pentanoyl]-n-pyridin-2-yl-l-isoleucinamide; (2R,3S)-3-(Formyl-hydroxyamino)-2-(2-methyl-1-propyl)-4-methylpentanoic acid, ((1S,2S)-2-methyl-1-(2-pyridylcarbamoyl)-1-butyl)amide; (2R,3S)-3-[formyl(hydroxy)amino]-4-methyl-N-[(2S,3S)-3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide
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| Drug Type |
Small molecular drug
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| Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Preclinical | [536223] | ||
| Company |
GlaxoSmithKline
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| Structure |
|
Download2D MOL |
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| Formula |
C22H36N4O4
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| Canonical SMILES |
CCC(C)C(C(=O)NC1=CC=CC=N1)NC(=O)C(CC(C)C)C(C(C)C)N(C=O)<br />O
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| InChI |
1S/C22H36N4O4/c1-7-16(6)19(22(29)24-18-10-8-9-11-23-18)25-21(28)17(12-14(2)3)20(15(4)5)26(30)13-27/h8-11,13-17,19-20,30H,7,12H2,1-6H3,(H,25,28)(H,23,24,29)/t16-,17+,19-,20-/m0/s1
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| InChIKey |
SMZPWUUYPYYHIV-HNJRGHQBSA-N
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| CAS Number |
CAS 212609-68-2
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | ADAM 17 | Target Info | Inhibitor | [536223] | |
| Pathway Interaction Database | ErbB4 signaling events | ||||
| TNF receptor signaling pathway | |||||
| p75(NTR)-mediated signaling | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Collagen degradation | |||||
| Regulated proteolysis of p75NTR | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| TNF signaling | |||||
| Growth hormone receptor signaling | |||||
| References | |||||
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