Drug Information

Drug General Information
Drug ID
D03SNI
Former ID
DNC008438
Drug Name
VUF-10148
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529387]
Structure
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2D MOL

3D MOL
Formula
C20H22N4
Canonical SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2CC4=CC=CC=C4
InChI
1S/C20H22N4/c1-23-11-13-24(14-12-23)20-19(15-16-7-3-2-4-8-16)21-17-9-5-6-10-18(17)22-20/h2-10H,11-15H2,1H3
InChIKey
PQQUQVYOCGJWAX-UHFFFAOYSA-N
PubChem Compound ID
24759623
Target and Pathway
Target(s) Histamine H2 receptor Target Info Inhibitor [529387]
Histamine H1 receptor Target Info Inhibitor [529387]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 529387J Med Chem. 2008 Apr 24;51(8):2457-67. Epub 2008 Mar 22.Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Ref 529387J Med Chem. 2008 Apr 24;51(8):2457-67. Epub 2008 Mar 22.Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

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