Drug General Information
Drug ID	D04DQZ
Former ID	DIB010761
Drug Name	AZD-2327
Synonyms	Opioid receptor delta agonist (anxiety, depression), AstraZeneca
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Phase 2	[522445]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Formula	C29H35FN4O
Canonical SMILES	c1(ccc(cc1)[C@@H](N1CCN(CC1)Cc1ccc(cc1)F)c1cc(ccc1)N)C(<br />=O)N(CC)CC
PubChem Compound ID	11525765
Target and Pathway
Target(s)	Delta-type opioid receptor	Target Info	Agonist	[531414]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522445	ClinicalTrials.gov (NCT00759395) Study of Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder (AMDD). U.S. National Institutes of Health.
Ref 531414	Preclinical pharmacology of AZD2327: a highly selective agonist of the delta-opioid receptor. J Pharmacol Exp Ther. 2011 Jul;338(1):195-204.

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