Drug General Information
Drug ID
D05JHA
Former ID
DNC013436
Drug Name
H-Tyr-c[cys-Gly-Phe(p-NO2)-cys]NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528724]
Structure
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2D MOL

3D MOL

Formula
C26H31N7O8S2
Canonical SMILES
C1C(C(=O)NCC(=O)NC(C(=O)NC(CSS1)C(=O)N)CC2=CC=C(C=C2)[N<br />+](=O)[O-])NC(=O)C(CC3=CC=C(C=C3)O)N
InChI
1S/C26H31N7O8S2/c27-18(9-14-3-7-17(34)8-4-14)24(37)32-21-13-43-42-12-20(23(28)36)31-26(39)19(30-22(35)11-29-25(21)38)10-15-1-5-16(6-2-15)33(40)41/h1-8,18-21,34H,9-13,27H2,(H2,28,36)(H,29,38)(H,30,35)(H,31,39)(H,32,37)/t18-,19-,20-,21-/m0/s1
InChIKey
NBZQMFLIMSGMAF-TUFLPTIASA-N
PubChem Compound ID
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Inhibitor [528724]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528724Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. Epub 2007 Feb 2.Further studies of tyrosine surrogates in opioid receptor peptide ligands.
Ref 528724Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. Epub 2007 Feb 2.Further studies of tyrosine surrogates in opioid receptor peptide ligands.

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