Drug Information

Drug General Information
Drug ID
D05WXF
Former ID
DIB021050
Drug Name
thiochrome
Synonyms
thiachrome
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540419]
Structure
Download
2D MOL
Formula
C12H14N4OS
InChI
InChI=1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3
InChIKey
GTQXMAIXVFLYKF-UHFFFAOYSA-N
PubChem Compound ID
66706
PubChem Substance ID
105767, 7685183, 8190668, 14996298, 24900483, 26746580, 43123393, 57316218, 57654703, 80017672, 85089873, 103145236, 104337259, 117405338, 117521565, 119525958, 135024574, 135651256, 142893272, 162091688, 163204727, 176323041, 198957115, 247762712
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [526926]
Muscarinic acetylcholine receptor M3 Target Info Modulator (allosteric modulator) [526926]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
GPCRs, Other
References
Ref 540419(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 348).
Ref 526926Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66.

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