Drug General Information
Drug ID	D05ZGQ
Drug Name	Dexchlorpheniramine Maleate
Synonyms	Dexchlorpheniramine Maleate; Polaramine
Drug Type	Small molecular drug
Indication	Rhinitis; Urticaria; Allergy [ICD10:J00, J30, J31.0, L50, T78.4]		Approved	[551871]
Company	Schering Corp Sub Schering Plough Corp
Structure		Download 2D MOL
Formula	C20H23ClN2O4
PubChem Compound ID	5281070
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator	[556264]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 556264	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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