Drug Information

Drug General Information
Drug ID
D06DWQ
Former ID
DIB004230
Drug Name
TOPIXANTRONE HYDROCHLORIDE
Synonyms
BBR-3576; Topixantrone hydrochloride < Prop INNM; BBR-3409 (dimaleate); 5-[2-(Dimethylamino)ethylamino]-2-[2-(2-hydroxyethylamino)ethyl]indazolo[4,3-gh]isoquinolin-6(2H)-one dihydrochloride
Drug Type
Small molecular drug
Indication Gastric cancer [ICD9: 151; ICD10:C16] Discontinued in Phase 2 [547312]
Structure
Download
2D MOL

3D MOL
Formula
C21H28Cl2N6O2
Canonical SMILES
CN(C)CCNc1ccc2c3c(nn2CCNCCO)c4cnccc4C(=O)c13
InChI
1S/C21H26N6O2/c1-26(2)10-8-24-16-3-4-17-19-18(16)21(29)14-5-6-23-13-15(14)20(19)25-27(17)11-7-22-9-12-28/h3-6,13,22,24,28H,7-12H2,1-2H3
InChIKey
ZHAKYGFJVGCOAE-UHFFFAOYSA-N
PubChem Compound ID
6918273
Target and Pathway
Target(s) Human DNA Target Info Inhibitor [550571]
References
Ref 547312Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015071)
Ref 550571Clinical pipeline report, company report or official report of CTI BioPharma.

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