Drug Information

Drug General Information
Drug ID
D06MAJ
Former ID
DAP001403
Drug Name
Mizolastine
Synonyms
Mistalin; Mistamine; Mizolastina; Mizolastinum; Mizolen; Mizollen; Zolim; Zolistam; Zolistan; Allphar brand of mizolastine; Galderma brand of mizolastine; Mizolastine [INN]; Novag brand of mizolastine; Sanofi Synthelabo brand of mizolastine; Schwarz brand of mizolastine; MKC-431; Mizolastina [INN-Spanish]; Mizolastinum [INN-Latin]; Mizollen (TN); SL 85.0324; Mizolastine (JAN/INN); SL-85.0324; 2-((1-(1-(p-Fluorobenzyl)-2-benzimidazolyl)-4-piperidyl)methylamino)-4(3H)-pyrimidinone; 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [535216]
Therapeutic Class
Antiallergic Agents
Structure
Download
2D MOL

3D MOL
Formula
C24H25FN6O
Canonical SMILES
CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(<br />=O)N5
InChI
1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)
InChIKey
PVLJETXTTWAYEW-UHFFFAOYSA-N
CAS Number
CAS 108612-45-9
PubChem Compound ID
65906
PubChem Substance ID
7848180, 8190025, 12014077, 14783219, 14856657, 43122645, 49846691, 50036887, 50125752, 50713968, 57315819, 81041146, 89736146, 92714282, 96099817, 103305895, 104334988, 109692956, 118843605, 125337563, 126624261, 126655525, 126666541, 127327796, 127327797, 127327798, 127327799, 127327800, 127327801, 127327802, 128973914, 131294183, 134338611, 135024365, 135692425, 137246302, 137267724, 138213095, 142886695, 144206216, 160828705, 162178211, 163093678, 163390269, 163842321, 164230570, 164812773, 170465604, 172914175, 174526115
SuperDrug ATC ID
R06AX25
SuperDrug CAS ID
cas=108612459
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536717]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 535216Population pharmacokinetic analysis and optimization of the experimental design for mizolastine solution in children. J Pharmacokinet Pharmacodyn. 2001 Jun;28(3):299-319.
Ref 536717Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanisms. Clin Exp Allergy. 2008 Jun;38(6):947-56.

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