Drug General Information
Drug ID	D06VST
Former ID	DNC004147
Drug Name	3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551235]
Structure		Download 2D MOL 3D MOL
Formula	C12H19NO
Canonical SMILES	CC(CC#CCN1CCCC1)C(=O)C
InChI	1S/C12H19NO/c1-11(12(2)14)7-3-4-8-13-9-5-6-10-13/h11H,5-10H2,1-2H3
InChIKey	FFWLTEFDRQBMQC-UHFFFAOYSA-N
PubChem Compound ID	15685977
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[551235]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[551235]
	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[551235]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[551235]
	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[551235]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
PathWhiz Pathway	Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
References
Ref 551235	Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).
Ref 551235	Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).

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