Drug Information

Drug General Information
Drug ID
D07MME
Former ID
DIB012296
Drug Name
Dexamethasone palmitate
Synonyms
Cortiject; Dexamethasone palmitate, Novagali; NOVA-22026; NOVA-22032; NOVA-63035; Corticosteroid therapy (ophthalmic emulsion, Novasorb), Novagali; Retinopathy therapy (ophthalmic emulsion, Novasorb), Novagali
Drug Type
Small molecular drug
Indication Choroidal neovascularisation [ICD10:H35] Phase 1/2 [551624]
Company
Santen
Structure
Download
2D MOL

3D MOL
Formula
C38H59FO6
Canonical SMILES
[C@H]12[C@H]3[C@@]([C@@]4(C(=CC(=O)C=C4)CC3)C)([C@H](C[<br />C@@]1([C@]([C@@H](C2)C)(C(=O)COC(=O)CCCCCCCCCCCCCCC)O)C<br />)O)F
PubChem Compound ID
63044
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Agonist [526384]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 551624Clinical pipeline report, company report or official report of Santen Pharmaceutical.
Ref 526384Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet. 2002 Jul 20;360(9328):211-8.

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