Drug Information

Drug General Information
Drug ID
D07QXU
Former ID
DCL000900
Drug Name
NS 2359
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder; Depression; Cocaine addiction [ICD9: 303-304, 304.2, 311, 314.00, 314.01; ICD10:F10-F19, F14.2, F32, F90] Discontinued in Phase 2 [536580]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C15H19Cl2NO
Canonical SMILES
COCC1C2CCC(N2)CC1C3=CC(=C(C=C3)Cl)Cl
InChI
1S/C15H19Cl2NO/c1-19-8-12-11(7-10-3-5-15(12)18-10)9-2-4-13(16)14(17)6-9/h2,4,6,10-12,15,18H,3,5,7-8H2,1H3/t10-,11+,12+,15+/m0/s1
InChIKey
FPTPUYCHSWIWIB-FUTJPDQTSA-N
CAS Number
CAS 843660-54-8
PubChem Compound ID
11408320
PubChem Substance ID
42487457, 53776739, 53857726, 75769703, 134339295, 134339352, 137009519, 224078872, 228731770, 244385659
Target and Pathway
Target(s) Dopamine reuptake Target Info Inhibitor [536499]
Sodium-dependent serotonin transporter Target Info Inhibitor [536499]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536499]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536499Emerging drugs for attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2007 Sep;12(3):423-34.

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