Drug Information

Drug General Information
Drug ID
D08HRJ
Former ID
DAP000337
Drug Name
Cyclizine
Synonyms
Ciclizina; Cyclizinum; Emoquil; Marezine; Nautazine; Valoid; Wellcome; Cyclizine chloride; Cyclizine hydrochloride; Marezine hydrochloride; BW 47-83; Ciclizina [INN-Spanish]; Cyclizine (INN); Cyclizinum [INN-Latin]; Emoquil (TN); Marezine (TN); Marzine (TN); Ne-devomit; Neo-devomit; Reis-fit; Valoid (TN); Wellcome preparation 47-83; Wellcome prepn 47-83; Cyclizine [INN:BAN:DCF]; Wellcome prepn. 47-83; N-Benzhydryl-N'-methylpiperazine; N-Methyl-N'-benzhydrylpiperazine; N-Methyl-N'-benzyhydrylpiperazine; (+-)-1-diphenylmethyl-4-methylpiperazine; (-)-1-Diphenylmethyl-4-methylpiperazine; (N-Benzhydryl)(N'-methyl)diethylenediamine; 1-(Diphenylmethyl)-4-methylpiperazine; 1-Benzhydryl-4-methylpiperazin; 1-Benzhydryl-4-methylpiperazine; 1-Diphenylmethyl-4-methylpiperazine
Drug Type
Small molecular drug
Indication Nausea; Vomiting [ICD9: 787, 787.0; ICD10:R11] Approved [538421], [542159]
Therapeutic Class
Antiemetics
Company
Seatrace Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C18H22N2
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3
InChIKey
UVKZSORBKUEBAZ-UHFFFAOYSA-N
CAS Number
CAS 82-92-8
PubChem Compound ID
6726
PubChem Substance ID
9147, 87441, 7625538, 7979006, 8154360, 10536697, 11112316, 11342188, 11362371, 11363748, 11366310, 11368872, 11371415, 11373948, 11377034, 11466538, 11467658, 11484923, 11486096, 11487773, 11488990, 11490184, 11492020, 11494668, 15197232, 17397725, 26611677, 26679882, 26747952, 26747953, 29225675, 46506232, 47440552, 47662546, 47960014, 47960015, 48035410, 48035411, 48185245, 48415824, 49698831, 50012930, 56394858, 57323665, 80297363, 85209423, 85787928, 85789538, 92123944, 92307358
ChEBI ID
ChEBI:3994
SuperDrug ATC ID
R06AE03
SuperDrug CAS ID
cas=000082928
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535368], [535716], [537890]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538421FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009495.
Ref 542159(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7151).
Ref 535368Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery. Anaesthesia. 2002 Jan;57(1):61-5.
Ref 535716Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6.
Ref 537890Synthesis and combined H1-/H2 antagonist activity of mepyramine, pheniramine and cyclizine derivatives with cyanoguanidine, urea and nitroethenediamine partial structures. Arch Pharm (Weinheim). 1994Jul;327(7):455-62.

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