Drug Information

Drug General Information
Drug ID
D08SLS
Former ID
DIB018882
Drug Name
arpromidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538733]
Structure
Download
2D MOL
Formula
C21H25FN6
InChI
InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27)
InChIKey
KZZIVOLMJPSDEP-UHFFFAOYSA-N
PubChem Compound ID
65895
PubChem Substance ID
14829347, 43122634, 48105231, 48179747, 57315813, 77686899, 85208956, 103248875, 104334955, 117509725, 128459163, 135024187, 135649957, 136352271, 163355082, 179294084, 180100806, 226505419, 235085534
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [526569]
Histamine H2 receptor Target Info Agonist [527955]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Gastric acid secretion
PANTHER Pathway Histamine H1 receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signaling
References
Ref 538733(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1221).
Ref 526569Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.
Ref 527955Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4.

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