Drug Information

Drug General Information
Drug ID
D08ZCL
Former ID
DNC000871
Drug Name
Leu-enkephalin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538990]
Structure
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2D MOL

3D MOL
Formula
C28H37N5O7
InChI
InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)
InChIKey
URLZCHNOLZSCCA-UHFFFAOYSA-N
CAS Number
CAS 380843-75-4
PubChem Compound ID
3903
PubChem Substance ID
463335, 6899007, 8149844, 8152458, 11336185, 11361424, 11364323, 11366885, 11369447, 11372501, 11374455, 11377609, 11462396, 11484929, 11488993, 11491336, 11492862, 11495243, 26681013, 29223017, 47662380, 47662381, 47736579, 48185073, 49997088, 50123045, 57309626, 57322044, 79293996, 85085815, 85209574, 99302098, 103177895, 103852107, 104304853, 117367196, 124638086, 125701316, 125821620, 126686033, 129410134, 135003516, 135651802, 137067622, 140543347, 162092134, 163144251, 177748293, 179038761, 184532295
ChEBI ID
ChEBI:39112
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [535152]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538990(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1613).
Ref 535152Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia. J Pharmacol Exp Ther. 2001 May;297(2):582-9.

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