Drug General Information
Drug ID
D08ZKN
Former ID
DCL000002
Drug Name
PG-530742
Synonyms
PG 116800; PG 530742; PGE 530742; PGE 7113313; PG-116800
Drug Type
Small molecular drug
Indication Osteoarthritis; Myocardial infarction [ICD9: 410, 715; ICD10:I21, I22, M15-M19, M47] Discontinued in Phase 2 [536172]
Company
Pharmagenesis
Structure
Download
2D MOL

3D MOL

Formula
C23H25N3O7S
Canonical SMILES
COC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC(C#CCN3CCO<br />CC3)C(=O)O
InChI
1S/C23H25N3O7S/c1-32-19-8-4-17(5-9-19)22(27)24-18-6-10-20(11-7-18)34(30,31)25-21(23(28)29)3-2-12-26-13-15-33-16-14-26/h4-11,21,25H,12-16H2,1H3,(H,24,27)(H,28,29)
InChIKey
WJDDDFUBTYNDPP-UHFFFAOYSA-N
CAS Number
CAS 291533-11-4
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Stromelysin-1 Target Info Inhibitor [528049], [536172]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map ST
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by Gastrin
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 536172Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. Epub 2006 Jan 20.
Ref 528049Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39.
Ref 536172Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. Epub 2006 Jan 20.

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