Drug Information

Drug General Information
Drug ID
D09RJN
Former ID
DIB004393
Drug Name
S-17092-1
Synonyms
S-17092 (undefined isomer); (2S,3aS,7aS)-1-[(1R,2R)-2-Phenylcyclopropylcarbonyl]-2-(thiazolidin-3-ylcarbonyl)perhydroindole
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 1 [546918]
Structure
Download
2D MOL

3D MOL
Formula
C22H28N2O2S
Canonical SMILES
C1CCC2C(C1)CC(N2C(=O)C3CC3C4=CC=CC=C4)C(=O)N5CCSC5
InChI
1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
InChIKey
NXSXRIHXEQSYEZ-KNJMJIDISA-N
CAS Number
CAS 176797-26-5
PubChem Compound ID
9929984
PubChem Substance ID
14902684, 24205539, 79493472, 103755589, 104151179, 135984099, 162247436, 178103179, 226553422
Target and Pathway
Target(s) Prolyl endopeptidase Target Info Inhibitor [526549]
KEGG Pathway Renin-angiotensin system
PANTHER Pathway Vasopressin synthesis
References
Ref 546918Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011104)
Ref 526549Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. J Neurochem. 2003 Mar;84(5):919-29.

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