TTD | Drug: D09UGP

Drug General Information
Drug ID	D09UGP
Former ID	DIB016832
Drug Name	RPR-106541
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[546303]
Company	Aventis Pharma AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@@]12([C@@]3([C@H]([C@H]4[C@@]([C@@]5(C(=CC(=O)CC5)[C<br />@H](C4)F)C)([C@H](C3)O)F)C[C@H]1O[C@H](O2)CCC)C)SC
CAS Number	CAS 159001-35-1
Target and Pathway
Target(s)	Steroid hormone receptor ERR1	Target Info	Agonist	[525541]
Reactome	PPARA activates gene expression
	Transcriptional activation of mitochondrial biogenesis
	Nuclear Receptor transcription pathway
WikiPathways	Mitochondrial Gene Expression
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Nuclear Receptors
References
Ref 546303	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007341)
Ref 525541	Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602.

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Drug Information