Drug Information

Drug General Information
Drug ID
D0AJ5L
Former ID
DAP001414
Drug Name
Oxatomide
Synonyms
Celtect; Oxatimide; Oxatomida; Oxatomidum; Oxetal; Tinset; CBMicro_024634; KW 4354; O 9387; R 35443; R35443; Celtect (TN); KW-4354; McN-JR 35443; Oxatomida [INN-Spanish]; Oxatomide (tinset); Oxatomidum [INN-Latin]; R 35,443; R-35443; Oxatomide (JAN/USAN/INN); Oxatomide [USAN:BAN:INN:JAN]; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone; 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-1,3-dihydro-benzoimidazol-2-one; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-2-benzimidazolinone; 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
Drug Type
Small molecular drug
Indication Hay fever [ICD9: 477; ICD10:J30] Approved [536700]
Therapeutic Class
Antiallergic Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C27H30N4O
Canonical SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C<br />5
InChI
1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChIKey
BAINIUMDFURPJM-UHFFFAOYSA-N
CAS Number
CAS 60607-34-3
PubChem Compound ID
4615
PubChem Substance ID
454767, 855791, 3356790, 7434788, 7848836, 8076407, 8152832, 10589929, 11111579, 11171328, 12013337, 14782886, 17405482, 17447408, 24278615, 29223704, 47515476, 48259415, 49883312, 50100302, 50106789, 50106790, 53778030, 57322351, 78738974, 81093279, 85174443, 85231171, 89007468, 92304200, 92308943, 96099872, 103175665, 103928643, 104306919, 105054418, 124609729, 124799800, 124881005, 124881006, 125354189, 126685859, 127327792, 127327793, 127486604, 131320626, 134338621, 135260589, 137156392, 137260958
SuperDrug ATC ID
R06AE06
SuperDrug CAS ID
cas=060576138
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535848], [536700]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.
Ref 535848Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. J Allergy Clin Immunol. 2003 Oct;112(4 Suppl):S78-82.
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.

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