Drug Information

Drug General Information
Drug ID
D0AR0H
Former ID
DNC008188
Drug Name
FM1-43
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529178]
Structure
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2D MOL

3D MOL
Formula
C30H49Br2N3
Canonical SMILES
CCCCN(CCCC)C1=CC=C(C=C1)C=CC2=CC=[N+](C=C2)CCC[N+](CC)(<br />CC)CC.[Br-].[Br-]
InChI
1S/C30H49N3.2BrH/c1-6-11-23-32(24-12-7-2)30-18-16-28(17-19-30)14-15-29-20-25-31(26-21-29)22-13-27-33(8-3,9-4)10-5;;/h14-21,25-26H,6-13,22-24,27H2,1-5H3;2*1H/q+2;;/p-2
InChIKey
VZUVCAGXYLMFEC-UHFFFAOYSA-L
PubChem Compound ID
6508724
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Inhibitor [529178]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [529178]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [529178]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [529178]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [529178]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCRs, Other
References
Ref 529178Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. Epub 2007 Nov 17.Design and synthesis of a fluorescent muscarinic antagonist.
Ref 529178Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. Epub 2007 Nov 17.Design and synthesis of a fluorescent muscarinic antagonist.

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