Drug Information

Drug General Information
Drug ID
D0B4RU
Former ID
DIB016240
Drug Name
Pregnenolone
Synonyms
Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 4 [523578], [539512]
Company
Duke University
Structure
Download
2D MOL

3D MOL
Formula
C21H32O2
InChI
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChIKey
ORNBQBCIOKFOEO-QGVNFLHTSA-N
PubChem Compound ID
8955
PubChem Substance ID
3095, 5056, 841801, 3136425, 7847211, 7889910, 8143499, 8156371, 10321800, 11466574, 11467694, 11486248, 12157331, 14850333, 24702313, 24887880, 24899008, 25621392, 29227585, 46506718, 47275669, 47646662, 48094643, 48318548, 48394039, 49698547, 50019742, 50111369, 50952978, 53790378, 56463239, 57325339, 85165262, 87574922, 90451278, 92125557, 92298073, 92309191, 92712002, 93167037, 93576762, 103557063, 103845983, 103914285, 104319171, 121363228, 124812051, 124892396, 126630318, 126656995
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Agonist [528119]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 523578ClinicalTrials.gov (NCT01409096) Study Using Pregnenolone to Treat Bipolar Depression. U.S. National Institutes of Health.
Ref 539512(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2376).
Ref 528119Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.