Drug Information

Drug General Information
Drug ID
D0C9ZE
Former ID
DNC003654
Drug Name
Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525826]
Structure
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2D MOL

3D MOL
Formula
C14H17NO2
Canonical SMILES
C1CC2CC(C(C1)N2)OC(=O)C3=CC=CC=C3
InChI
1S/C14H17NO2/c16-14(10-5-2-1-3-6-10)17-13-9-11-7-4-8-12(13)15-11/h1-3,5-6,11-13,15H,4,7-9H2
InChIKey
AKLGENRCHBXEKW-UHFFFAOYSA-N
PubChem Compound ID
10105296
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Inhibitor [525826]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [525826]
Muscarinic acetylcholine receptor M4 Target Info Inhibitor [525826]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [525826]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [525826]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04080:Neuroactive ligand-receptor interaction
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCRs, Other
References
Ref 525826J Med Chem. 2000 Jun 29;43(13):2514-22.6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Ref 525826J Med Chem. 2000 Jun 29;43(13):2514-22.6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.

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