Drug Information

Drug General Information
Drug ID
D0CS2F
Former ID
DAP000425
Drug Name
Loperamide
Synonyms
Ioperamide; Loperacap; Loperamida; Loperamidum; Kaopectate II; Loperamide Monohydrochloride; Pepto Diarrhea Control; Apo-Loperamide; Diamide (TN); Diarr-Eze; Dimor (TN); Imodium (TN); Imodium A-D Caplets; Loperamida [INN-Spanish]; Loperamide (INN); Loperamide [INN:BAN]; Loperamidum [INN-Latin]; Lopex (TN); Maalox Anti-Diarrheal; Nu-Loperamide; PMS-Loperamide; Pepto (TN); R-18553; Rho-Loperamide; 2-methoxyethyl1-methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(4-Chlorophenyl)-N,N-dimethyl-.alpha.,.alpha.-diphenyl-4-hydroxy-1-piperidinebutanamide; 4-(4-Chlorophenyl)-N,N-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidinebutanamide; 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Drug Type
Small molecular drug
Indication Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease [ICD10:K50, K60] Approved [551871]
Therapeutic Class
Antidiarrheals
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C29H33ClN2O2
InChI
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChIKey
RDOIQAHITMMDAJ-UHFFFAOYSA-N
CAS Number
CAS 53179-11-6
PubChem Compound ID
3955
PubChem Substance ID
9291, 5686070, 7979790, 8152483, 10590039, 11111380, 11112740, 11113732, 11119963, 11120451, 11120939, 11121446, 11121926, 11147046, 11335390, 11360629, 11362515, 11363268, 11365077, 11365830, 11367639, 11368392, 11370301, 11370302, 11372088, 11373240, 11374823, 11375801, 11376554, 11461601, 11466172, 11467292, 11485552, 11485923, 11489554, 11490830, 11492957, 11494188, 14809921, 26751916, 26751917, 29223069, 46504591, 47216522, 47364910, 47515062, 47515063, 47588737, 47662002, 47662003
SuperDrug ATC ID
A07DA03
SuperDrug CAS ID
cas=053179116
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Binder [537797]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537797Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8.

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