Drug Information

Drug General Information
Drug ID
D0D0ZQ
Former ID
DNC008289
Drug Name
MERIOLIN 6
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529275]
Structure
Download
2D MOL

3D MOL
Formula
C14H15N5O
Canonical SMILES
CC(C)OC1=C2C(=CNC2=NC=C1)C3=NC(=NC=C3)N
InChI
1S/C14H15N5O/c1-8(2)20-11-4-6-16-13-12(11)9(7-18-13)10-3-5-17-14(15)19-10/h3-8H,1-2H3,(H,16,18)(H2,15,17,19)
InChIKey
YRURITXEWXPMAI-UHFFFAOYSA-N
PubChem Compound ID
24801185
Target and Pathway
Target(s) Cell division protein kinase 9 Target Info Inhibitor [529275]
Cyclin-A2 Target Info Inhibitor [529275]
Cell division protein kinase 2 Target Info Inhibitor [529275]
KEGG Pathway Transcriptional misregulation in cancerhsa03030:DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
Cell cycle
Hepatitis B
HTLV-I infectionhsa04068:FoxO signaling pathway
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancer
NetPath Pathway EGFR1 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
IL2-mediated signaling events
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma protein
PathWhiz Pathway Nucleotide Excision Repair
Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-113510:E2F mediated regulation of DNA replication
G0 and Early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
G2 Phase
Orc1 removal from chromatin
G1/S-Specific Transcription
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-1538133:G0 and Early G1
Activation of ATR in response to replication stress
DNA Damage/Telomere Stress Induced Senescence
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet production
WikiPathways Cardiac Hypertrophic Response
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Host Interactions of HIV factors
HIV Life Cycle
IL-9 Signaling Pathway
RNA Polymerase II Transcription
MicroRNAs in cardiomyocyte hypertrophyWP615:Senescence and Autophagy in Cancer
Mismatch repair
DNA Replication
G1 to S cell cycle control
EGF/EGFR Signaling Pathway
S Phase
Nifedipine Activity
Primary Focal Segmental Glomerulosclerosis FSGS
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Nucleotide Excision Repair
Telomere Maintenance
Synthesis of DNA
Mitotic G1-G1/S phases
Cell Cycle
Base Excision RepairWP707:DNA Damage Response
ID signaling pathway
M/G1 Transition
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Spinal Cord Injury
Oncostatin M Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Regulation of DNA replication
Mitotic G2-G2/M phases
Factors involved in megakaryocyte development and platelet production
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 529275J Med Chem. 2008 Feb 28;51(4):737-51. Epub 2008 Jan 31.Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolincomplex.
Ref 529275J Med Chem. 2008 Feb 28;51(4):737-51. Epub 2008 Jan 31.Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolincomplex.

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