Drug Information

Drug General Information
Drug ID
D0D1HR
Former ID
DIB014995
Drug Name
TrkB NAM
Synonyms
TrkB negative allosteric modulators (neurodegenerative diseases); TrkB NAM program (neurodegenerative diseases), Addex; TrkB negative allosteric modulators (neurodegenerative diseases), Addex
Indication Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] Investigative [543504]
Company
Addex Pharmaceuticals SA
Target and Pathway
Target(s) BDNF/NT-3 growth factors receptor Target Info Modulator [543504]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholism
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signaling
Reactome NGF-independant TRKA activation
WikiPathways SIDS Susceptibility Pathways
BDNF signaling pathway
References
Ref 543504(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).
Ref 543504(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).

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