Drug Information

Drug General Information
Drug ID
D0F5JR
Former ID
DIB005036
Drug Name
ONO-1603
Synonyms
N-(4-Chlorobenzyl)-4-[2(S)-formylpyrrolidin-1-yl]-4-oxobutyramide
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 2 [545099]
Structure
Download
2D MOL

3D MOL
Formula
C16H19ClN2O4
Canonical SMILES
OC(=O)[C@@H]1CCCN1C(=O)CCC(=O)NCc2ccc(Cl)cc2
InChI
1S/C16H19ClN2O4/c17-12-5-3-11(4-6-12)10-18-14(20)7-8-15(21)19-9-1-2-13(19)16(22)23/h3-6,13H,1-2,7-10H2,(H,18,20)(H,22,23)/t13-/m0/s1
InChIKey
CYDZCFWTMBKLOW-ZDUSSCGKSA-N
PubChem Compound ID
46889286
Target and Pathway
Target(s) Prolyl endopeptidase Target Info Modulator [534253]
KEGG Pathway Renin-angiotensin system
PANTHER Pathway Vasopressin synthesis
References
Ref 545099Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002119)
Ref 534253ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4.

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