Drug General Information
Drug ID	D0FQ4M
Former ID	DIB014549
Drug Name	Selenotifen
Synonyms	BN-52256
Indication	Asthma [ICD10:J45]		Terminated	[544859]
Company	Ipsen
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12C(=C3CCN(CC3)C)c3c(CC(=O)c1[se]cc2)cccc3
CAS Number	CAS 135472-91-2
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator	[527929]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544859	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001341)
Ref 527929	Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. Pharmacol Res. 1992 Feb-Mar;25(2):173-80.

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