Drug General Information
Drug ID	D0L5YF
Former ID	DIB010867
Drug Name	ZD-4190
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Terminated	[546662]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Formula	C19H17BrClFN6O2
Canonical SMILES	c12c(Nc3c(cc(cc3)Br)F)ncnc1cc(c(c2)OC)OCCn1nncc1.Cl
CAS Number	CAS 257938-36-6
PubChem Compound ID	6918394
Target and Pathway
Target(s)	VEGF receptor	Target Info	Modulator	[525712]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Transcriptional misregulation in cancer
	Rheumatoid arthritis
References
Ref 546662	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009540)
Ref 525712	ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. 2000 Feb 15;60(4):970-5.

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