Drug Information

Drug General Information
Drug ID
D0L9IA
Former ID
DCL000816
Drug Name
Glufosfamide
Synonyms
Glucosylifostamide mustard; D 19575; D-19575; Glc-IPM; Glucosyl-ifosfamide mustard; Beta-D-Glucopyranose 1-(N,N'-bis(2-chloroethyl)phosphorodiamidate; Beta-D-Glucopyranose, 1-(N,N'-bis(2-chloroethyl)phosphorodiamidate); (2S,3R,4S,5S,6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,5-triol
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Discontinued in Phase 2 [536839]
Company
Threshold Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C10H21Cl2N2O7P
Canonical SMILES
C(CCl)NP(=O)(NCCCl)OC1C(C(C(C(O1)CO)O)O)O
InChI
1S/C10H21Cl2N2O7P/c11-1-3-13-22(19,14-4-2-12)21-10-9(18)8(17)7(16)6(5-15)20-10/h6-10,15-18H,1-5H2,(H2,13,14,19)/t6-,7-,8+,9-,10+/m1/s1
InChIKey
PSVUJBVBCOISSP-SPFKKGSWSA-N
CAS Number
CAS 132682-98-5
PubChem Compound ID
123628
PubChem Substance ID
10240805, 12014754, 14829496, 15449605, 29303857, 49972504, 50329410, 57340491, 104418945, 126682194, 134224761, 134339290, 135079098, 137267500, 160708922, 162172133, 179149819, 184547964, 186024302, 198964639, 223657839, 226408271
Target and Pathway
Target(s) Human DNA Target Info Modulator
References
Ref 536839Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.

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