Drug General Information
Drug ID	D0M4PH
Former ID	DIB009174
Drug Name	LOXO-101
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[524734]
Company	Array biopharma; loxo oncology
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	BDNF/NT-3 growth factors receptor	Target Info	Inhibitor	[543504]
	Trk receptor	Target Info	Inhibitor	[532994]
	Neurotrophic tyrosine kinase receptor 1	Target Info	Inhibitor	[551954]
KEGG Pathway	MAPK signaling pathway
	Neurotrophin signaling pathway
	Alcoholismhsa04010:MAPK signaling pathway
	Endocytosis
	Apoptosis
	Inflammatory mediator regulation of TRP channels
	Pathways in cancer
	Transcriptional misregulation in cancer
	Thyroid cancer
	Central carbon metabolism in cancer
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	SHP2 signaling
	Posttranslational regulation of adherens junction stability and dissassembly
	Neurotrophic factor-mediated Trk receptor signalingtrkrpathway:Neurotrophic factor-mediated Trk receptor signaling
Reactome	NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation
	NGF-independant TRKA activation
	PI3K/AKT activationR-HSA-170968:Frs2-mediated activation
	ARMS-mediated activation
	PI3K/AKT activation
WikiPathways	SIDS Susceptibility Pathways
	BDNF signaling pathwayWP382:MAPK Signaling Pathway
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	NGF signalling via TRKA from the plasma membraneWP382:MAPK Signaling Pathway
	NGF signalling via TRKA from the plasma membrane
References
Ref 524734	ClinicalTrials.gov (NCT02122913) Oral TRK Inhibitor LOXO-101 for Treatment of Advanced Adult Solid Tumors. U.S. National Institutes of Health.
Ref 532994	ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39.
Ref 543504	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).
Ref 551954	Clinical pipeline report, company report or official report of Loxo Oncology.

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