Drug Information

Drug General Information
Drug ID
D0M8PW
Former ID
DAP001397
Drug Name
Levocetirizine dihydrochloride
Synonyms
Xyzal; Xyzall; Levocetirizine HCl; Levocetirizine dihydrochloride [USAN]; Levocetirizine hydrochloride; Levocetirizine 2HCl; KS-1177; Levocetirizine hydrochloride (JAN); Vozet (TN); Xozal (TN); Xusal (TN); Xuzal (TN); Xyzal (TN); Xyzall (TN); Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride; (2-(4-((R)-(4-Chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [538587], [538725]
Therapeutic Class
Antiallergic Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C21H25ClN2O3
InChI
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
InChIKey
ZKLPARSLTMPFCP-OAQYLSRUSA-N
CAS Number
CAS 130018-77-8
PubChem Compound ID
1549000
PubChem Substance ID
11545046, 14927596, 26719822, 32248928, 46386593, 47583669, 47805464, 48179644, 48253864, 49681558, 49861381, 50276924, 51091738, 57409063, 92308500, 92714143, 93166949, 93302554, 103771174, 110525158, 124659008, 124799922, 126629651, 126655634, 126670860, 131297234, 134338605, 135107372, 135650416, 136211813, 136351130, 137001886, 139283254, 143494987, 152235888, 162258150, 163423572, 164837925, 172080394, 172859038, 175267409, 175270481, 179149784, 184548289, 184654357, 196111560, 211534825, 223258882, 223582092, 223657396
SuperDrug ATC ID
R06AE09
SuperDrug CAS ID
cas=130018778
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535339], [536700], [537072]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538587FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022064.
Ref 538725(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1214).
Ref 535339Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. Pol J Pharmacol. 2001 Jan-Feb;53(1):93-6.
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.
Ref 537072Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.

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