Drug General Information
Drug ID
D0MH1X
Former ID
DIB018931
Drug Name
AZD1332
Synonyms
AZD 1332; AZD-1332
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542676]
Structure
Download
2D MOL
Formula
C17H19ClFN7O
InChI
InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
InChIKey
LBVKEEFIPBQIMD-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Trk receptor Target Info Inhibitor [543503]
BDNF/NT-3 growth factors receptor Target Info Inhibitor [543504]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholism
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signaling
Reactome ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-187024:NGF-independant TRKA activation
WikiPathways MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP706:SIDS Susceptibility Pathways
References
Ref 542676(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7700).
Ref 543503(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817).
Ref 543504(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).

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