Drug General Information
Drug ID	D0N1RG
Former ID	DIB014091
Drug Name	SoRI-9409
Drug Type	Small molecular drug
Indication	Alcohol use disorders [ICD9: 303; ICD10:F10.2]		Preclinical	[548793]
Company	Southern Research Institute
Structure		Download 2D MOL 3D MOL
Formula	C29H27ClN2O3
Canonical SMILES	[C@]123[C@@]4([C@H](N(CC5CC5)CC3)Cc3c1c(O[C@H]2c1c(C4)c<br />c(cn1)c1ccc(cc1)Cl)c(cc3)O)O
CAS Number	CAS 248273-61-2
PubChem Compound ID	9805452
Target and Pathway
Target(s)	Delta-type opioid receptor	Target Info	Antagonist	[526028]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548793	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028893)
Ref 526028	In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. J Pharmacol Exp Ther. 2001 May;297(2):597-605.

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