Drug Information

Drug General Information
Drug ID
D0O7JW
Former ID
DAP001553
Drug Name
Alcaftadine
Synonyms
Lastacaft (TN)
Drug Type
Small molecular drug
Indication Allergic conjunctivitis [ICD9: 204.0, 372.0, 372.14, 995.3; ICD10:C91.0, H10, H10.45, T78.4] Approved [531351], [542577]
Company
Vistakon Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H21N3O
InChI
InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
InChIKey
MWTBKTRZPHJQLH-UHFFFAOYSA-N
CAS Number
CAS 147084-10-4
PubChem Compound ID
19371515
PubChem Substance ID
32035600, 47208208, 54762049, 56342212, 99443288, 103771483, 135213415, 135811086, 136349963, 136946466, 137154653, 141465597, 144115577, 160646397, 160967905, 175268090, 175437720, 189561500, 210275577, 210281225, 223365922, 223659717, 227796404, 241036820, 251971063, 252451458, 252553073
SuperDrug ATC ID
S01GX11
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [531351]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 542577(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7587).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.

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