Drug General Information
Drug ID
D0PW4N
Former ID
DCL000139
Drug Name
Ispinesib
Synonyms
SB-715992; Ispinesib (SB-715992 /CK0238273); SB-715992, CK0238273,Ispinesib; N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide
Drug Type
Small molecular drug
Indication Head and neck cancer; Renal cell carcinoma; Ovarian cancer; Solid tumors [ICD9: 140-149, 140-199, 140-229, 183, 189, 210-229; ICD10:C07-C14, C32-C33, C56, C64, D10-D36, D3A] Phase 2 [521617]
Therapeutic Class
Anticancer Agents
Company
Cytokinetics
Structure
Download
2D MOL

3D MOL

Formula
C30H33ClN4O2
Canonical SMILES
CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C=CC(=C3)Cl)C(=O)N<br />2CC4=CC=CC=C4)C(C)C
InChI
1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1
InChIKey
QJZRFPJCWMNVAV-HHHXNRCGSA-N
CAS Number
CAS 514820-03-2
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Kinesin-like protein KIF11 Target Info Inhibitor [536879], [537505], [537526]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 521617ClinicalTrials.gov (NCT00095628) SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer. U.S. National Institutes of Health.
Ref 536879Gateways to clinical trials. July-August 2008. Methods Find Exp Clin Pharmacol. 2008 Jul-Aug;30(6):459-95.
Ref 537505KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain? BMC Cancer. 2009 Jun 22;9:196.
Ref 537526Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Jun 24.

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