Drug Information

Drug General Information
Drug ID
D0R4UW
Former ID
DCL000964
Drug Name
Roflumilast
Synonyms
DAXAS; ROF; Roflumilast [USAN]; BY217; BYK20869; APTA-2217; BY-217; Roflumilast (JAN/USAN/INN); 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE; 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide; 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [531783], [541997]
Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Withdrawn from market [537075], [541997]
Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Discontinued in Phase 2 [537075], [541997]
Company
Nycomed US Inc; Altana
Structure
Download
2D MOL

3D MOL
Formula
C17H14Cl2F2N2O3
InChI
InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey
MNDBXUUTURYVHR-UHFFFAOYSA-N
CAS Number
CAS 162401-32-3
PubChem Compound ID
449193
PubChem Substance ID
7890296, 10300323, 12014977, 14879303, 36890842, 46393569, 46393577, 46515099, 47207405, 49876227, 50659842, 53788863, 57288829, 57404909, 58108277, 85239858, 87235814, 103463298, 104253463, 104640579, 109693509, 121279025, 124757594, 124772083, 125001902, 125164398, 125536640, 126618387, 126666054, 126731090, 128619725, 134339138, 134339348, 134339400, 134358320, 135114471, 136345716, 136946527, 137010091, 137269493, 142175980, 144223762, 160644734, 162011650, 162037767, 162201204, 163124095, 163406034, 163620892, 163686213
SuperDrug ATC ID
R03DX07
Target and Pathway
Target(s) PDE4 Target Info Modulator [531783]
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 537075Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009 Mar;14(1):165-79.
Ref 541997(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6962).
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.

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