Drug General Information
Drug ID
D0RD5S
Former ID
DNC003809
Drug Name
5,7-Dimethoxy-3-thiophen-3-yl-quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533862]
Structure
Download
2D MOL

3D MOL

Formula
C15H13NO2S
Canonical SMILES
COC1=CC2=NC=C(C=C2C(=C1)OC)C3=CSC=C3
InChI
1S/C15H13NO2S/c1-17-12-6-14-13(15(7-12)18-2)5-11(8-16-14)10-3-4-19-9-10/h3-9H,1-2H3
InChIKey
OOSYGDRIWJDGFV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Alpha platelet-derived growth factor receptor Target Info Inhibitor [533862]
Beta platelet-derived growth factor receptor Target Info Inhibitor [533862]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Choline metabolism in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
AngiogenesisWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
PDGF Pathway
References
Ref 533862J Med Chem. 1994 Jul 8;37(14):2129-37.A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives.
Ref 533862J Med Chem. 1994 Jul 8;37(14):2129-37.A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives.

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