Drug Information

Drug General Information
Drug ID
D0S9YX
Former ID
DIB018977
Drug Name
biochanin A
Synonyms
4'-methylgenistein
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539870]
Structure
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2D MOL

3D MOL
Formula
C16H12O5
InChI
InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3
InChIKey
WUADCCWRTIWANL-UHFFFAOYSA-N
PubChem Compound ID
5280373
PubChem Substance ID
4072, 416963, 605430, 855738, 6896514, 8140097, 8144597, 8150182, 8616243, 11113288, 11336202, 11361441, 11363089, 11365651, 11368213, 11372095, 11375412, 11376375, 11404953, 11462413, 11483909, 11487863, 11490913, 11493741, 11494009, 14799798, 24893597, 26611560, 26679994, 26746976, 26751494, 29203891, 39289535, 46510178, 47365294, 47515401, 47589077, 47959856, 48334590, 48421900, 49684192, 49889542, 50100559, 50104034, 50123128, 50135482, 51062354, 53788092, 56422868, 57357716
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Agonist [526891]
Estrogen-related receptor-gamma Target Info Agonist [526891]
Estrogen-related receptor-beta Target Info Agonist [526891]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 539870(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2829).
Ref 526891Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91.

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