Drug General Information
Drug ID	D0VZ8S
Former ID	DIB007124
Drug Name	KA-398
Synonyms	Scopinast; Scopinast, Wilmar Schwabe
Indication	Asthma [ICD10:J45]		Terminated	[546278]
Company	Dr Willmar Schwabe GmbH & Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12oc(=O)ccc2cc(c(c1)OCCCN1CCC(C(c2ccc(cc2)F)(c2ccc(cc2<br />)F)O)CC1)OC
CAS Number	CAS 145574-90-9
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator	[543664]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546278	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007218)
Ref 543664	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 262).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.