Drug Information

Drug General Information
Drug ID
D0W9ZT
Former ID
DND000037
Drug Name
ADL-5859
Synonyms
PF-04856880
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [522241]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C24H29ClN2O3
Canonical SMILES
CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O<br />.Cl
InChI
1S/C24H28N2O3.ClH/c1-3-26(4-2)23(28)18-10-8-17(9-11-18)19-16-24(12-14-25-15-13-24)29-21-7-5-6-20(27)22(19)21;/h5-11,16,25,27H,3-4,12-15H2,1-2H3;1H
InChIKey
ZFNLSWREIULTDO-UHFFFAOYSA-N
PubChem Compound ID
46931003
PubChem Substance ID
99437293, 120933844, 123051121, 126582657, 126723477, 135727817, 136340320, 136367453, 152258434, 160647270, 162011381, 162038088, 162202785, 164045117, 172918052, 174530929, 185980621, 189622861, 202546480, 223704844, 242060206, 252109887, 252160419, 252214670, 252451812
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [543762]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522241ClinicalTrials.gov (NCT00626275) Study Evaluating the Analgesic Efficacy and Safety of ADL5859 in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 543762(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.