Drug General Information
Drug ID	D0X6OV
Former ID	DIB021070
Drug Name	toxaphene
Synonyms	octachlorocamphene
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539872]
Structure		Download 2D MOL
Formula	C10H8Cl8
InChI	InChI=1S/C10H8Cl8/c1-4-7(2-11,3-12)9(16)6(14)5(13)8(4,15)10(9,17)18/h5-6H,1-3H2
InChIKey	OEJNXTAZZBRGDN-UHFFFAOYSA-N
PubChem Compound ID	5284469
PubChem Substance ID	17389704, 29157103, 39317800, 48414557, 48421768, 48424195, 48425693, 57359078, 78747868, 113862954, 124891500, 124891501, 135650755, 136077376, 137171673, 144204724, 144208110, 162224237, 180422974, 231707701, 242362134
Target and Pathway
Target(s)	Steroid hormone receptor ERR1	Target Info	Antagonist	[525591]
Reactome	PPARA activates gene expression
	Transcriptional activation of mitochondrial biogenesis
	Nuclear Receptor transcription pathway
WikiPathways	Mitochondrial Gene Expression
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Nuclear Receptors
References
Ref 539872	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2830).
Ref 525591	Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24.

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