Drug Information

Drug General Information
Drug ID
D0X9RG
Former ID
DAP000214
Drug Name
Butorphanol
Synonyms
Beforal; Butorfanol; Butorphanolum; Moradol; Stadol; Butorphanol tartrate; BC-2627; Beforal (TN); Butorfanol [INN-Spanish]; Butorphanolum [INN-Latin]; L-BC 2627; Moradol (TN); Butorphanol (USAN/INN); Butorphanol [USAN:BAN:INN]; Levo-BC-2627; (-)-17-(Cyclobutylmethyl)morphinan-3,14-diol; (-)-N-cyclobutylmethyl-3,14-dihydroxymorphinan; (-)-butorphanol; 17-(CYCLOBUTYLMETHYL)MORPHINAN-3,14-DIOL
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538290], [542581]
Therapeutic Class
Analgesics
Company
Apotex Inc
Structure
Download
2D MOL

3D MOL
Formula
C21H29NO2
InChI
InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1
InChIKey
IFKLAQQSCNILHL-QHAWAJNXSA-N
CAS Number
CAS 58786-99-5
PubChem Compound ID
5361092
PubChem Substance ID
9081, 14801765, 14875085, 17397351, 32960763, 48415674, 49992740, 50631323, 57371628, 92729940, 93166707, 103205944, 104098285, 126666040, 134224509, 135000864, 136280316, 137005108, 139157626, 160963956, 163074576, 164837504, 175265477, 179150474, 198993287, 223365926, 223670035, 224782792, 226395864, 241079392, 250136746, 252346885
SuperDrug ATC ID
N02AF01
SuperDrug CAS ID
cas=042408822
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [536098]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538290FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075046.
Ref 542581(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7591).
Ref 536098Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. Epub 2005 Jun 8.

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