Drug General Information
Drug ID	D0Y0ZB
Former ID	DIB007442
Drug Name	SB-219825
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[546476]
Company	SmithKline Beecham Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1([nH]c2c(c1C)C[C@@H]1[C@](C2)(c2cc(O)ccc2)CCN(C1)CC)C<br />(=O)N(CC)CC
CAS Number	CAS 194798-70-4
Target and Pathway
Target(s)	Delta-type opioid receptor	Target Info	Modulator	[526061]
KEGG Pathway	cGMP-PKG signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
	Opioid proenkephalin pathway
	Opioid proopiomelanocortin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546476	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008418)
Ref 526061	Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sci. 2001 Apr 6;68(19-20):2233-42.

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