Drug Information

Drug General Information
Drug ID
D0Y4SP
Former ID
DNC000771
Drug Name
ICI 154129
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537722]
Structure
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2D MOL

3D MOL
Formula
C34H46N4O6S
Canonical SMILES
CC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)SCCNC(=O)CNC(=O)C(C<br />C2=CC=C(C=C2)O)N(CC=C)CC=C
InChI
1S/C34H46N4O6S/c1-5-17-38(18-6-2)29(21-26-12-14-27(39)15-13-26)32(41)36-23-31(40)35-16-19-45-30(22-25-10-8-7-9-11-25)33(42)37-28(34(43)44)20-24(3)4/h5-15,24,28-30,39H,1-2,16-23H2,3-4H3,(H,35,40)(H,36,41)(H,37,42)(H,43,44)/t28-,29-,30-/m0/s1
InChIKey
CZRZYRKTYLLLRL-DTXPUJKBSA-N
CAS Number
CAS 83420-94-4
PubChem Compound ID
3035055
PubChem Substance ID
10048256, 22395473, 36078614, 50065282, 57353022, 74705388, 111638076, 134223808, 134339046, 134340110, 135072263, 135698148, 198945650, 230337472, 241181917, 241377494
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Antagonist [537722]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 537722In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor. Neuropharmacology. 1985 Feb;24(2):107-10.
Ref 537722In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor. Neuropharmacology. 1985 Feb;24(2):107-10.

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