Resistance mutation info of target

Target General Information
Target ID T03818
Target Name Peroxisome proliferator-activated receptor gamma (PPARG) Target Info
Gene Name PPARG
Species Homo sapiens
Uniprot ID PPARG_HUMAN
Sequence MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Ref 468126(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5012).
Mutation Info Missense: P465L
Drugs
Drug Name Insulin Drug Info [1559266]
Targeted Disease Hyperglycemia and lipodystrophy
Mutation Info Missense: P467L
Drugs
Drug Name Insulin Drug Info [1559266]
Targeted Disease Hyperglycemia and lipodystrophy
Reference
Ref 1559266Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Diabetes.2010 Nov;59(11):2890-7.

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