Target General Information
Target ID T51076
Target Name Trk receptor
Synonyms GP145TrkC; NT3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC; TrkC tyrosine kinase; NTRK3
Target Type Clinical Trial
Gene Name NTRK3
Biochemical Class Kinase
UniProt ID NTRK3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Alzheimer's disease
Example drug MK-2461 Phase 1/2 [530708], [1572592]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.14
Z-score: -0.43
P-value: 7.06E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 530708MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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