Target expression details
Target General Information | |||||
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Target ID | T97613 | ||||
Target Name | Melatonin receptor type 1A | ||||
Synonyms | Mel1AR; Mel1a receptor; MTNR1A | ||||
Target Type | Successful | ||||
Gene Name | MTNR1A | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID | MTR1A_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Depression | ||||
Example drug | Agomelatine | Withdrawn from market | [536580], [539276], [1572592] | ||
Tissue | Pre-frontal cortex | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.08 Z-score: -0.54 P-value: 5.71E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 539276 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 198). |
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