Target Validation Information
Target ID T92403
Target Name Sodium/hydrogen exchanger 3
Target Type
Clinical Trial
Drug Potency against Target HOE-694 Drug Info IC50 = 130 nM [534413]
N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine Drug Info IC50 = 210 nM [534413]
N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine Drug Info IC50 = 150 nM [534413]
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine Drug Info IC50 = 380 nM [534413]
N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine Drug Info IC50 = 270 nM [534413]
N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine Drug Info IC50 = 180 nM [534413]
N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine Drug Info IC50 = 140 nM [534413]
CARIPORIDE Drug Info IC50 = 26 nM [534705]
ENIPORIDE Drug Info IC50 = 8 nM [534705]
References
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534413J Med Chem. 1997 Jun 20;40(13):2017-34.(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Ref 534705J Med Chem. 1998 Sep 10;41(19):3736-47.Bicyclic acylguanidine Na+/H+ antiporter inhibitors.
Ref 534705J Med Chem. 1998 Sep 10;41(19):3736-47.Bicyclic acylguanidine Na+/H+ antiporter inhibitors.

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