| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T28705 | ||||
| Target Name | mRNA of Caspase 8 | ||||
| Target Type | Research |
||||
| Drug Potency against Target | PRALNACASAN | Drug Info | IC50 = 40 nM | [528340] | |
| Isoquinoline-1,3,4(2H)-trione | Drug Info | IC50 = 1910 nM | [528057] | ||
| Ac-IETD-CHO | Drug Info | IC50 = 4.2 nM | [530042] | ||
| References | |||||
| Ref 528340 | Bioorg Med Chem Lett. 2006 Sep 15;16(18):4728-32. Epub 2006 Jul 25.Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors. | ||||
| Ref 528057 | J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. | ||||
| Ref 530042 | J Med Chem. 2009 Apr 23;52(8):2188-91.Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. | ||||
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